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Biofolate® Folic Acid

Biofolate®, an active form of folate. Safeguard life of all ages.

Product Name: Calcium L-5-Methyltetrahydrofolate (L-5-MTHF-Ca)

CAS No. :151533-22-1

Folate (vitamin B9) is an essential vitamin that the human body cannot synthesize alone. It plays a crucial role in the growth and reproduction of body cells. A deficiency of folate can have detrimental effects on the normal physiological activities of the human body.

BIRTH DEFECTS PREVENTION
HEART HEALTH PROTECTION
MOOD MANAGEMENT
COGNITIVE IMPROVEMENT

About Folate

According to WHO Guideline: daily iron and folic acid supplementation in pregnant women (2012), it is recommended that pregnant women take 0.4 mg of folic acid daily to improve maternal and infant health.

Why Biofolate®?

Biofolate^® L-5-Methyltetrahydrofolate Calcium (L-5-MTHF-Ca) is an active form of folate that the body can readily utilize. It helps mitigate potential risks linked to folate metabolism disorders and provides vital health support for individuals of all ages throughout their lives.

Biofolate® v.s. Folic Acid

Our bodies need folic acid, but it must be changed into a usable form first. This change happens through a process controlled by an enzyme called Methyltetrahydrofolate, or MTHF. Many people have small differences in their MTHFR genes, which can affect how well their bodies process folic acid. These people might have trouble using folic acid properly without even knowing it.

Metabolism of Folic Acid

The metabolism of folic acid in the body involves a series of enzymatic reactions and cofactors. The folic acid that enters the body is converted to L-5-MTHF, a biologically active form, through the action of various enzymes. Among these enzymes, MTHFR is a key enzyme in variation that affects the conversion of folic acid in the body and is the main enzyme leading to hereditary folate malabsorption.

Folic Acid Metabolism Disorder

The survey shows that many of the population in Mexico, northern China, and parts of Europe and the US have genetic variants associated with folic acid metabolism disorders. Given the substantial prevalence of these genetic risk factors across different regions, direct folic acid supplementation may not be as effective for these populations.

Absorption Comparison

Blood concentrations of active folic acid were significantly higher in individuals taking Biofolate^® compared to those taking regular folic acid, effectively bypassing the effects of genetic variations. As a result, Biofolate^® is a more effective source of folic acid.

Suitable Crowd

Folate is essential for health at every stage of life. It supports mood, enhances beauty, and contributes to overall well-being. For women preparing for or during pregnancy, folate helps reduce the risk of congenital heart defects in infants. It also provides critical nutrition for babies, children, and adolescents, while promoting the health of adults and seniors.

Infants, Children, and Adolescents
Motherhood Support
Heart Health for Seniors

Infants, Children, and Adolescents

Folate is vital for growth and development. A deficiency can result in delayed growth and anemia, which affects the blood’s oxygen-carrying capacity, leading to fatigue, dizziness, and palpitations.

Motherhood Support

Neural tube defects (NTDs) are a significant birth defect linked to low folate levels before and during early pregnancy. Studies show that folate supplementation during pregnancy can effectively reduce the risk of congenital heart defects.

Heart Health for Seniors

Folate helps lower elevated homocysteine levels in the blood, reducing the risk of cardiovascular disease and stroke. Additionally, a folate deficiency may contribute to cognitive decline in older adults, including memory loss and decreased mental function. Research also indicates that low folate levels can lead to cardiovascular issues like high blood pressure.

Technology

Higher bioavailability: Biofolate^® can be absorbed directly without the influence of folate-metabolism-related enzymes.

More nutrition: Biofolate^® provides calcium.

Strict quality control: Strictly controlled for over ten impurity indicators according to USP standards. We deliver safe and high-quality products.

Higher purity: Active ingredient content > 98%.

Outstanding stability: Water activity less than 0.15 can maintain long-lasting stability at room temperature.

Versatile application: Pure white powder, can be easily applied to various forms of product: powders, capsules, tablets, and more.

Qualification Assurance

Frequently Asked Questions About Biofolate® Folic Acid

01 What's the difference between folate and folic acid?
Folate and folic acid are essentially the form of vitamin B9. Folate is a naturally occurring form, while folic acid is a man-made form that appears in supplements or fortified foods. Both forms of vitamin B9 can support cell function and immune health, preventing health problems like anemia, neural tube defects, etc. Unlike some vitamins, B9 cannot be synthesized by the body, so dietary intake or supplementation is required. Folic acid supplements are necessary for maintaining the B9 levels in the body and can be challenging at every stage of life.
02 What is the most effective folic acid?
5-MTHF methylated folate supplement is the most reliable form for higher folic acid bioavailability. Supplementation of Biofolate® folic acid can successfully bypass the whole process of folic acid metabolism, unlocking the full potential of folic acid.
03 What is folic acid metabolism disorder?
Folate (in natural food) and folic acid supplements (man-made form) both need to be converted into a bioactive form (5-Methyltetrahydrofolate, also called 5-MTHF) to be used. Approximately 10-15% of people carry a genetic variant that reduces enzyme efficiency for this process. Most do not realize it until they are diagnosed with folate deficiency. That’s why methylated folate supplements (which provide B9 in its active form) are increasingly popular.
04 How to take folic acid supplements properly?
There is no required time during the day to take folic acid. However, to maximize the full potential of folic acid, it is required to take folic acid before having a meal (empty stomach) with plenty of water.

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Safeguard life of all ages.

Reference available upon request.
The content on this page is for business use only and is not intended for end consumers.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Information on this site is provided for informational purposes only. It is not meant to substitute for medical advice from your physician or other medical professional. You should not use the information contained herein to diagnose or treat a health problem or disease or prescribe any medication. Carefully read all product documentation. If you have or suspect that you have a medical problem, promptly contact your regular healthcare provider.

Biofolate^® is a trademark of EffePharm Ltd.

Choose the Right Methylated Folate Supplements for Better Absorption

Folate plays an essential role in prenatal health, energy metabolism, and cognitive function. Even so, not every folate supplement is equally effective. A lot of people are using folic acid supplements, that must be changed in the body into its active form, methylfolate, before it can be used. However, this conversion may not be effective for everyone because of certain gene variations such as MTHFR mutations.

According to many health professionals, it is better to use additional methylated folate—the active form of this vitamin that your body can utilize, without any changes. For example, there is Biofolate® active folic acid, a product of EffePharm that is a methylfolate ingredient backed by clinical trials. Made for the best stability, cleanness, and absorption, makes it more eligible for the higher intake of people.

Support Your Health with Biofolate®

When dealing with pregnancy nutrition, cardiovascular health, or mood balance, the type of folate you have chosen represents the reason for the success of your venture. Skip ineffective folic acid supplements your body struggles to metabolize. Instead, choose methylated folate supplements that are known and guaranteed to be efficient and bioavailable.

For more information on Biofolate® and science-driven nutritional ingredients, visit effepharm.com.