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Fisetin

Precision Senolytic Action for Cellular Renewal.

Product Name: Fisetin

CAS No. :528-48-3

SENESCENT CELL CLEARANCE
ANTIOXIDANT SUPPORT
ANTI-INFLAMMATION
AUTOPHAGY ACTIVATION
MITOCHONDRIAL HEALTH SUPPORT
COGNITIVE FUNCTION ENHANCEMENT

About Fisetin

Fisetin is a natural flavonoid found in strawberries, apples, onions, and other fruits and vegetables. Studies show that Fiestin offers multiple health benefits, including antioxidant, anti-inflammatory, and neuroprotective effects.

Most notably, fisetin may help clear senescent cells—aging cells that contribute to inflammation and age-related decline. Leading journals such as EBioMedicine^[1] and Aging^[2] have recognized fisetin as a potential breakthrough compound in the field of senolytics and longevity science.

Targeting Aging at the Cellular Level

Fisetin and Senescent Cells

Senescent cells are damaged or aging cells that stop dividing but refuse to die. Over time, they build up in the body and release harmful molecules that trigger chronic inflammation and tissue damage, key drivers of age-related diseases^[3].

Recent research shows that fisetin may help eliminate senescent cells, making it a promising natural compound for healthy aging. By targeting these cells, fisetin supports cellular renewal and helps reduce inflammation at the source.

Fisetin Powder

A Natural Senolytic Supplement Backed by Research

The concept of senolytic supplements was first introduced in 2015 by Dr. James L. Kirkland’s team at the Mayo Clinic, marking a breakthrough in aging research^[4]. In 2017, the same team published a study in Aging identifying fisetin powder as a powerful natural senolytic compound capable of selectively clearing senescent cells without damaging healthy ones^[2].

Thanks to its ability to remove dysfunctional cells and restore tissue balance, fisetin has become one of the most researched ingredients in the senolytic category, showing strong potential in healthy aging and longevity-focused supplement formulations.

A Leading Natural Senolytic Supplement

In a 2018 comparative study by Mayo Clinic, fisetin demonstrated the most potent senolytic activity among 11 natural flavonoids—effectively clearing senescent cells, restoring tissue homeostasis, and extending both median and maximum lifespan in aged mice^[1].

Beyond its role as a senolytic supplement, fisetin supports cellular health through autophagy activation, mitochondrial stabilization, antioxidant effects, and anti-inflammation—these multi-pathway benefits position fisetin powder as a high-potential ingredient for healthy aging and longevity applications.

Technology

High Purity: Fisetin powder with ≥99% purity, meeting the standards for premium applications.

High Content: Over 99% active ingredient, with excellent stability.

Ultra-Pure: Minimal impurities; no black residues in solvents.

100% Allergen-Free: Suitable for allergen-sensitive formulations.

Qualification Assurance

Frequently Asked Questions About Fisetin

01 Which food is highest in fisetin?
Fisetin is a natural flavonoid found in various fruits and vegetables. Among these, strawberries contain the highest concentration of fisetin, making them a top dietary source. Other notable sources include apples, grapes, onions, and cucumbers. However, to achieve therapeutic benefits, many turn to pure fisetin supplements or fisetin powder for more concentrated doses.
02 Who shouldn’t take fisetin?
While fisetin powder and other senolytic supplements are generally considered safe, certain groups should exercise caution. Pregnant or breastfeeding women, individuals taking blood thinners or other medications, and those with specific medical conditions should consult a healthcare professional before using fisetin supplements. Personalized advice is essential to avoid potential interactions.
03 How much fisetin should I take daily?
There is no universally established daily dose for fisetin. However, most senolytic supplements recommend doses ranging from 100 mg to 500 mg of pure fisetin per day, depending on the formulation and intended use. Always follow the product guidelines or seek medical advice to determine the appropriate dosage for your needs.
04 What are senolytic supplements?
Senolytic supplements are a class of compounds designed to selectively remove senescent cells—aged or dysfunctional cells that accumulate in the body over time. By clearing these cells, senolytic supplements like fisetin powder help reduce chronic inflammation, improve tissue function, and support healthy aging. Pure fisetin is recognized as one of the most potent natural senolytic agents currently studied.

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Reference available upon request.
The content on this page is for business use only and is not intended for end consumers.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Information on this site is provided for informational purposes only. It is not meant to substitute for medical advice from your physician or other medical professional. You should not use the information contained herein to diagnose or treat a health problem or disease or prescribe any medication. Carefully read all product documentation. If you have or suspect that you have a medical problem, promptly contact your regular healthcare provider.

Reference

[1] Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., McGuckian, C., Wade, E. A., Kato, J. I., Grassi, D., Wentworth, M., Burd, C. E., Arriaga, E. A., Ladiges, W. L., Tchkonia, T., & Kirkland, J. L. (2018). Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine, 36, 18–28. https://doi.org/10.1016/j.ebiom.2018.09.015

[2] Zhu, Y., Doornebal, E. J., Pirtskhalava, T., Giorgadze, N., Wentworth, M., Fuhrmann-Stroissnigg, H., Niedernhofer, L. J., Robbins, P. D., Tchkonia, T., & Kirkland, J. L. (2017). New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463. Aging, 9(3), 955– https://doi.org/10.18632/aging.101202

[3] Gasek, N. S., Kuchel, G. A., Kirkland, J. L., & Xu, M. (2021). Strategies for targeting senescent cells in human disease. Nature Aging, 1(10), 870– https://doi.org/10.1038/s43587-021-00121-8

[4] Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., O’Hara, S. P., LaRusso, N. F., Miller, J. D., Roos, C. M., Verzosa, G. C., LeBrasseur, N. K., Wren, J. D., Farr, J. N., Khosla, S., & Stout, M. B. (2015). The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell, 14(4), 644–658. https://doi.org/10.1111/acel.12344

Discover the Best Fisetin Supplement for Healthy Aging and Senolytic

As a leading fisetin supplier, EffePharm is committed to delivering premium-quality fisetin powder that meets the highest industry standards. Our products undergo rigorous quality control to ensure purity, potency, and consistency, making us the trusted partner for nutraceutical brands worldwide.

Looking to buy fisetin powder in bulk? EffePharm offers competitive pricing and reliable supply chains to support your manufacturing needs. Whether you require small batches for research or large-scale production, our efficient logistics and expert customer service ensure timely delivery and seamless procurement.

As one of the top fisetin powder manufacturers, EffePharm specializes in producing pure fisetin with purity levels exceeding 99%. Our state-of-the-art production facilities and advanced extraction technologies guarantee a product free of impurities, making it ideal for premium fisetin supplements and functional formulations.

Choose EffePharm for your fisetin powder needs and benefit from our dedication to quality, consistency, and transparency. Our pure fisetin serves as a powerful natural ingredient in formulations designed to promote healthy aging, cognitive support, and antioxidant protection, positioning your products at the forefront of the market.

With EffePharm’s high-quality fisetin powder, you gain access to one of the best fisetin supplement ingredients available. Partner with us to enhance your product portfolio with an ingredient recognized globally for its potent senolytic and antioxidant properties.

Learn more about our cutting-edge ingredient innovations and why we’re a leading fisetin bulk powder provider at Effepharm.com.