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UTHEVER® NMN

β-Nicotinamide Mononucleotide (NMN)

UTHEVER® NMN（β-Nicotinamide Mononucleotide）

CAS No. :1094-61-7

NCT Number: NCT04228640

World’s First Clinically Proven NMN brand.

No.1 NMN Ingredient Brand in the USA

SHOWCASING ANTIAGING PROPERTIES
CARDIOVASCULAR PROTECTION
ALLEVIATING DEPRESSION
BOOSTING COGNITIVE FUNCTION
AIDING WEIGHT MANAGEMENT

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About NMN

β-Nicotinamide Mononucleotide (NMN) is a derivative of vitamin B3, which plays a crucial role in human cell functions. NMN can be naturally produced in cells or obtained through fruits, vegetables, and poultry. Research shows that NMN is a bioactive compound that can boost cellular NAD+ levels. As we age, NAD+ levels in the body decline. Supplementing NAD+ can effectively slow down aging and improve the prevention and management of age-related diseases.

Mechanisms of NMN

Increase NAD+ levels
Activate "longevity protein" sirtuins
Repair DNA damage
Promote energy production

UTHEVER, No.1 trademarketed NMN in the US

Why UTHEVER® NMN

UTHEVER® NMN — The No.1 Trademarked, Clinically Proven NMN

UTHEVER® NMN is the world’s first clinically proven NMN brand, a distinction that established the scientific benchmark for the category. Built on this foundation, UTHEVER® NMN has become the No.1 trademarked NMN ingredient in the United States*.

This leadership is backed by more than market adoption. UTHEVER® NMN is supported by a multicentre, randomized, double-blind, placebo-controlled human clinical study demonstrating its efficacy and safety^[1]. Choosing UTHEVER® means combining proven science with proven market acceptance, delivering confidence and credibility in a competitive NMN market.

Because we are ROOTED IN SCIENTIFIC RESEARCH

Since its founding, UTHEVER^® has been firmly grounded in scientific research by supporting multiple scientific research projects to explore the potential benefits of NMN^[2][3][4].

Uthever NMN clinical findings

More about UTHEVER® NMN studies

Because we are TRUSTED BY GLOBAL BRANDS

The UTHEVER® trademark is licensed and used by more than 100 brands worldwide.

We are the innovation partner you can rely on, staunchly dedicated to providing efficient, science-based, and state-of-the-art solutions designed specifically for your consumers’ requirements. Our professional science, technology, and marketing staff are constantly working alongside your business, so that all product development is based on scientific research, goes through ethical safety testing, and is certified with data from human trial evaluations.

Being one of the top NMN supplier, UTHEVER® has been recognized for its clinically verified NMN ingredient, offering proven purity, stability, and bioavailability. By integrating clinical insights into product development, we help brands create supplements that meet market demands and stand out in competitive categories. Working hand-in-hand with you, we ensure your formulas not only meet regulatory and scientific standards but also deliver real, measurable benefits to consumers.

More about UTHEVER® NMN marketing support

Market Insights

According to the United Nations World Population Prospects 2022, the population above the age of 65 years is growing more rapidly than the population below that age. This means that the percentage of the global population aged 65 and above is expected to rise from 10% in 2022 to 16% in 2050. The rise of population aging continues to drive the demand for nutritious and health foods.

Technology

Smaller Capsule, Huge Impact

UTHEVER^® sets a G3 density standard in NMN production, making capsule filling more consumer-friendly.

G3 density improves fluidity, producing smaller, more easily swallowable capsules.
Provides G1/G2/G3 density specification.
Suitable for powder, tablets, capsules, and other dosage forms.

*G3 refers to ultra-high density NMN with a granule size of 0.6-0.8 g/ml.

Marketing Support

Marketing Insights

At EffePharm, we understand the pivotal role marketing plays in driving brand growth and fostering lasting connections with consumers. That’s why we’re thrilled to unveil this unprecedented opportunity for our clients. Partner with EffePharm today and unlock the full power of our market insights to drive smarter decisions and stronger results.

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Customer Site

To read more about UTHEVER^® NMN, or would like to find out UTHEVER^® NMN where to buy, visit uthever.com.

If you are a brand formulating with UTHEVER^® NMN and would like to be featured on our site, please contact us.

More About UTHEVER® NMN

Qualification
Assurance

UTHEVER® is an NPA 2023 member brand adhering to NPA standards.
Kosher, and halal certified.
Manufactured in IOS9001, cGMP facilities.

Frequently Asked Questions About UTHEVER® NMN

UTHEVER^® is the world’s first clinically proven branded NMN manufacturer, setting the benchmark for scientifically proven NMN supplements. UTHEVER^® provides high-quality NMN with an unparalleled purity higher than 99.8%. Increasingly, clinical trials on NMN have highlighted its potential to support overall well-being throughout the aging process as an NAD+ booster.

01 What is the current regulatory status of NMN in the United States?
Nicotinamide Mononucleotide (NMN) is widely studied as a precursor to NAD⁺, a molecule essential for cellular energy production, DNA repair, and healthy aging. In recent years, NMN’s regulatory pathway in the United States attracted industry attention due to evolving interpretations related to prior pharmaceutical research.

EffePharm is pleased to share that we have received a Letter of No Objection from the U.S. Food and Drug Administration (FDA) in response to our New Dietary Ingredient (NDI) notification for UTHEVER® NMN.

Being a leader in NMN clinical research, UTHEVER® is supported by a robust portfolio of human clinical trials evaluating safety and efficacy. Across published studies and regulatory submissions, NMN has demonstrated a strong safety profile when used as directed. We remains committed to scientific rigor, product quality, and regulatory compliance, ensuring that UTHEVER® NMN continues to meet the highest standards for consumers and partners worldwide.
02 Is NMN approved as a Novel Food in the EU?
Not yet—but progress is underway. NMN is currently not authorized as a Novel Food in the European Union. However, EffePharm’s UTHEVER® NMN is leading the regulatory application process. As of February 2025, it has successfully passed the public consultation stage and is now undergoing EFSA’s scientific risk assessment. Approval of UTHEVER® would mark a significant milestone in the EU, potentially opening broader access to compliant, high-purity NMN bulk supplier products and wholesale channels across Europe.
03 Are there any side effects of NMN?
NMN supplements are generally well-tolerated. Clinical and toxicology studies indicate a strong safety profile. That said, some individuals may experience mild side effects, such as gastrointestinal discomfort, nausea, or headaches. These are typically short-lived and resolve with proper dosage adjustment. Those purchasing from a reliable NMN supplement manufacturer often report noticeable energy and vitality improvements with minimal adverse effects.
04 Does NMN promote cancer cell growth?
No current research supports the idea that NMN increases cancer risk or accelerates cancer cell growth. In fact, emerging studies suggest that NMN, when combined with other nutrients, may even help enhance immune cell activity against abnormal cell proliferation. Some reports indicate a possible improvement in immune efficacy by around 30%[5]. For users seeking safe and effective formulations, choosing from a science-based NMN powder supplier ensures confidence and quality assurance.
05 Who should avoid taking NMN?
While NMN is considered safe for healthy adults aiming to boost NAD+ levels, individuals who are pregnant or breastfeeding should consult a healthcare provider before using NMN supplements, as specific studies in these groups remain limited. Choosing NMN capsules from a reputable manufacturer ensures better quality control, ingredient purity, and peace of mind.
06 How to Choose an NMN Supplement?
Choosing an NMN supplement that places the emphasis on being high-quality, pure, and evidence-based in clinical trials is a wise decision. A manufacturer of NMN that provides clear test reports, transparent sourcing, and consistent results should be prioritized. Research-backed certification and reliable NMN wholesale distribution are strong indicators of trustworthy products.

EffePharm’s UTHEVER® NMN stands out as the world’s first clinically proven NMN brand, offering unmatched credibility for those seeking clinically verified NMN. As a trusted NMN bulk supplier, we deliver the best nmn powder with high purity, excellent stability, and superior bioavailability—making it the ideal choice for both consumers and formulators. By prioritizing clinically supported NMN, you can confidently select a supplement that truly supports healthy aging and NAD⁺ restoration.

UTHEVER® – Endorsed by Science, Trusted by Experts

Dr. Richard Kaszynski

Science Consultant

Co-Founder and Director, Stanford Solutions Trustee, the ASHINAGA organization

"Enhancing human NAD+ levels is one of the anti-aging strategies supported by multiple Nobel-recognized studies. Supplementing with NAD+ precursors, such as NMN, is the simplest and most effective approach. UTHEVER® NMN is the most authentic and proven NMN product on the market, and it is also the first brand globally to undergo large-scale human clinical validation. We are currently conducting various anti-aging trials using UTHEVER® NMN, and we eagerly look forward to sharing the results with the public soon."

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Reference available upon request.
The content on this page is for business use only and is not intended for end consumers.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Information on this site is provided for informational purposes only. It is not meant to substitute for medical advice from your physician or other medical professional. You should not use the information contained herein to diagnose or treat a health problem or disease or prescribe any medication. Carefully read all product documentation. If you have or suspect that you have a medical problem, promptly contact your regular healthcare provider.

UTHEVER^® is a trademark of EffePharm Ltd.

Reference:

[1] Huang, Hao. “A Multicentre, Randomised, Double Blind, Parallel Design, Placebo Controlled Study to Evaluate the Efficacy and Safety of UTHEVER (NMN Supplement), an Orally Administered Supplementation in Middle Aged and Older Adults.” Frontiers in Aging, vol. 3, 5 May 2022, https://doi.org/10.3389/fragi.2022.851698. Accessed 2 June 2022.

[2] Zhou, Xianrong, et al. “β-Nicotinamide Mononucleotide (NMN) Administered by Intraperitoneal Injection Mediates Protection against UVB-Induced Skin Damage in Mice.” ProQuest, 2021, pp. 5165–5182, www.proquest.com/docview/2582553547?pq-origsite=primo, https://doi.org/10.2147/JIR.S327329. Accessed 15 Mar. 2022.

[3] Zhao, Xiaotong, et al. “NMN Ameliorated Radiation Induced Damage in NRF2-Deficient Cell and Mice via Regulating SIRT6 and SIRT7.” Free Radical Biology & Medicine, vol. 193, no. Pt 1, 2022, pp. 342–353, pubmed.ncbi.nlm.nih.gov/36252808/, https://doi.org/10.1016/j.freeradbiomed.2022.10.267.

[4] Jiang, Yisheng, et al. “Treatment of SARS-CoV-2-Induced Pneumonia with NAD+ and NMN in Two Mouse Models.” Cell Discovery, vol. 8, no. 1, 29 Apr. 2022, www.ncbi.nlm.nih.gov/pmc/articles/PMC9053567/, https://doi.org/10.1038/s41421-022-00409-y. Accessed 7 Jan. 2023.

[5] Sergei Boichuk, et al. “Enhancement of NK Cell Cytotoxic Activity and Immunoregulatory Effects of a Natural Product Supplement across a Wide Age Span: A 30-Day in Vivo Human Study.” International Journal of Molecular Sciences, vol. 26, no. 7, 22 Mar. 2025, pp. 2897–2897, https://doi.org/10.3390/ijms26072897. Accessed 1 Aug. 2025.

*Source: Euromonitor International Limited. Based on B2B sales volume of trademarked NMN ingredient brands in the USA in 2024. Trademarked NMN ingredient brand refers to a brand officially registered with a government trademark office, and destined to NMN (Nicotinamide Mononucleotide) ingredient, a bioactive compound that supports healthy aging by serving as a precursor to NAD+. Research completed in Dec 2025.

Why Choosing the Right NMN Manufacturer Matters in 2025

In the year 2025 when longevity supplements are multiplying at an incredible rate, a choice of reliable NMN supplement manufacturer should be the first point of attention consumers, researchers, and supplement brands have. EffePharm is one of the top NAD⁺ and NMN powder manufacturers in the world and is known for its commitment to purity, repeatability, and scientific innovation. As a result of a significant investment in NAD⁺ research, EffePharm not only remains a leading manufacturer of NMN but also is a bulk supplier of NMN that is the most trusted and highly appreciated by the industry for its advanced cellular health and technology which is the global standard.

At the core of this reputation lies EffePharm’s pharmaceutical-grade production system, where every batch meets tightly controlled specifications. Among its flagship offerings, the NMN powder is praised for exceptional purity and proven bioavailability, making it a trusted choice across global markets and consistently ranked among the top NMN supplements available through channels.

Backed by Research, Driven by Results

EffePharm stands apart from other NMN powder suppliers thanks to its scientific rigor and transparent approach. Under its exclusive UTHEVER® trademark, the company launched the world’s first clinically verified, pure, and extensively studied NMN ingredient. This in-depth research sheds light on NMN’s role in mitochondrial function, energy metabolism, and cellular longevity—building unparalleled confidence for those seeking the best NMN supplement 2025.

Such clinical evidence is like a strong arm for brands that care about people’s health and aim to create the future of supplements. When it comes to the top NMN powder, the main factors are the one that can be verified effectiveness and the total transparency of the product. EffePharm is just the right place where these two come together.

Versatile, Safe, and Scalable Solutions

EffePharm’s NMN powder is designed for maximum flexibility, suitable for capsules, tablets, sachets, and customized formulations. Available in bulk NMN quantities, it delivers high performance at competitive prices. Each batch undergoes stringent microbiological testing—covering total plate count, yeast & mold, E. coli, Salmonella, and coliforms—and carries full certifications to ensure global compliance.

It doesn’t matter if you are a brand new supplement company or a well-established firm that wants to broaden the NAD⁺ product line of your brand; collaborating with a reliable NMN manufacturer will grant you not only scalability but also trustworthiness.

Choose EffePharm – Your Trusted Source for the Best NMN Powder

In today’s highly competitive supplement industry, one of the smartest moves is to build a partnership with a scientifically proven manufacturer of NMN like EffePharm. With its thoroughly tested, pharmaceutical-grade products and global reputation for excellence, EffePharm leads the way as an innovative NMN wholesale and NMN powder manufacturer—advancing the field of longevity through education, research, and collaboration.

Experience the advantage of EffePharm, a product of scientific research and supplement quality, which is also the source of the top NMN powder, bulk NMN, and the finest NMN supplements of 2025.