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L-5-methyltetrahydrofolic acid is a major and common form of dietary folic acid in human circulation and is essential for human health.As a result, it is a folate that is often transported to peripheral tissues for cellular metabolism.

【Product Name】L-5-MTHF-Ca

【CAS NO.】151533-22-1

【Appearance】White Powder


【Application】Homocysteine control, prenatal care, treatment for cardiovascular disease, dementia, and depression


L-Methylfolate (5-MTHF) During Pregnancy

Active folic acid is highly protective against Neural Tube Defects.

This is why all national and international health organizations advocate for folic acid supplementation before and during early pregnancy. For those who do not metabolize folic acid well, supplementing L-Methylfolate is the clear alternative while pregnant. Especially if you have a homozygous C677T or A1298C mutation, which is thought to increase your folate requirements even more.


L-Methylfolate (5-MTHF) in depression

L-methylfolate is becoming widely recognised as an effective complementary medicine for patients with severe depression. That is, using italongside pharmaceutical drugs (SSRI) to enhance the overall effectiveness of treatment (much like fish oil and depression). Several randomised clinical trials have shown that 15 mg/day of L-methylfolate calcium is a safe, effective and well-tolerated treatment for patients with major depressive disorder who experience partial or no response to SSRIs. It appears to be particular effective in those with certain genetic variations (including MTHFR) and those with elevated inflammatory markers.


L-Methyfolate (5-MTHF) in patients with diabetic neuropathy

Diabetic neuropathy is nerve disorder that develops over time in those with poorly managed type 1 or type 2 diabetes.

In a recent study, 544 patients with diabetic neuropathy were given Metanx (L-methylfolate-methylcobalamin-pyridoxal-5-phosphate) to trial for over a year. Based on self-reported surveys, overall pain rating decreased by 32% those previously treated with medications reported a 52% improvement in medication satisfaction. Metanx is a combination vitamin B supplement, so this study did not test the effects of L-methylfolate on its own.