Want to Boost NAD+ as You Age? UTHEVER® NMN Might Be The Key

Introduction

As we age, our body’s natural NAD+ levels decline—an essential coenzyme involved in energy production, metabolism, and cellular repair. One promising way to counteract this decline is with Nicotinamide Mononucleotide (NMN), a well-researched molecule known for its role in supporting healthy aging.

UTHEVER^® NMN stands out in the wellness space as the first and NMN supplement backed by a human clinical trial. This groundbreaking study provides valuable insight into how NMN actually performs in the body—not just in theory, but in practice.

In this article, we break down the key findings from that trial and what they mean for those looking to maintain vitality, boost NAD+ levels, and support long-term wellness with the help of UTHEVER^® NMN.

Clinical Trial Overview: Real Science, Real People

To rigorously assess UTHEVER^® NMN’s impact on NAD+ levels and physical health, researchers conducted a randomized, double-blind, placebo-controlled study involving 66 healthy adults aged 40 to 65. Participants were randomly assigned to receive 300 mg/day of UTHEVER^® NMN or a placebo over a 60-day period.

Key health indicators were monitored at three checkpoints—baseline, day 30, and day 60—including:

• Serum NAD+/NADH levels
• Physical endurance (6-minute walk test)
• Quality of life (SF-36 questionnaire)
• Blood pressure and insulin resistance (HOMA-IR index)
• General safety markers

The study was conducted at two clinical sites under strict ethical oversight, helping ensure reliable and unbiased findings regarding the effects of UTHEVER^® NMN supplementation.

UTHEVER^® NMN does NOT increase the NAD+ level?

(Huang, 2022) Table 2. Comparison of changes in mean blood cellular NAD+/NADH between the groups. The UTHEVER^® NMN group’s sustained NAD+ rise— peaking at 38% by day 60 — highlights a time-dependent cumulative effect, strongly suggesting extended supplementation could amplify anti-aging benefits like NAD+ level enhancement.

To find out whether UTHEVER^® NMN could actually raise NAD+ levels in the body, researchers conducted a 60-day clinical study with healthy adults aged 40–65. Participants were split into two groups: one took 300 mg of UTHEVER^® NMN daily, while the other received a placebo. NAD+/NADH levels were then measured at the start, midway (day 30), and end (day 60) to track any changes.

According to the published results, the UTHEVER^® group showed an 11.3% increase in NAD+/NADH levels by day 30 and a 38% increase by day 60, calculated using the formula:

The results were clear. By day 30, the UTHEVER^® group’s NAD+/NADH levels increased by 11.3%, and by day 60, the levels rose by a significant 38%. In contrast, the placebo group saw virtually no change at day 30 and only a 14.3% increase at day 60—likely due to natural variability or placebo effect.

Improvements in Endurance and Quality of Life

Beyond NAD+ biomarkers, participants taking UTHEVER^® NMN also experienced measurable improvements in physical and mental well-being. In the 6-minute walk test, UTHEVER^® users showed steady gains in distance walked, reflecting enhanced endurance and mobility over time.

TABLE 3. Comparison of changes in total distance covered in (6 Minute Walk Test) between the groups.

When compared to the placebo group in which walking endurance improved transiently to day 30, the UTHEVER^® NMN group had a consistent and continued improvement to day 60, suggesting a time-dependent benefit. These had 6.5% improvement in general quality of life by day 60 (according to the SF-36 scale). Of interest, the largest differences were seen in vitality, emotional well-being and perceived general health— outcomes indicative of meaningful everyday differences rather than clinical outcomes.

No Negative Impact on Blood Sugar & No Safety Concerns

TABLE 6 Comparison of changes in mean HOMA IR index between groups. Existing data show that UTHEVER^® NMN does not contribute to the development of diabetes or induce insulin resistance.

In order to evaluate the effect of UTHEVER^® NMN on blood sugar and metabolic safety, the change of HOMA-IR, a commonly employed index of insulin resistance, was monitored. This is derived from fasting insulin and glucose:

Higher HOMA-IR score generally indicates a higher level of insulin resistance, which can lead to type 2 diabetes and other metabolic diseases. In this placebo-controlled 60-day clinical trial, 31 of the participants took UTHEVER^® NMN (exp. group), while the other 31 participants took a placebo.

The results? In the UTHEVER group, the HOMA-IR value did not change significantly, being 1.78 and 1.79. In comparison, the placebo group had a greater shift — from 1.83 to 2.39. This variability within the placebo group could be indicative of poorly controlled diet or lifestyle factors, rather than the supplementation per se.

Although some people may still wonder “is nmn legit” or worry about the risk of an nmn scam, studies like this offer scientific reassurance. UTHEVER^® NMN did not increase insulin resistance or glucose disturbance, attesting its safety in healthy adults. These findings align with broader nad booster review trends that confirm metabolic tolerance and clinical value.

While more studies are needed to verify NMN’s benefits for people with existing metabolic conditions, the current data—backed by research and reviewed alongside peer experts —strongly suggest that NMN is a safe NAD+ booster with no negative impact on blood sugar regulation.

Why UTHEVER^® NMN Stands Out in the Supplement Market

While NMN is widely recognized for its potential as a NAD+ booster, not all products are equal. Purity, stability, and scientific validation vary dramatically between brands. UTHEVER^® sets itself apart by:

• Publishing human clinical trial results in peer-reviewed journals
• Maintaining high purity standards (≥99%)
• Undergoing third-party testing and regulatory documentation, including EFSA Novel Food application

When choosing NMN supplements, it’s crucial to look beyond the label and ask: “Is there evidence?” With UTHEVER^®, the answer is yes—especially for those looking to identify the best nmn brands in today’s market. Among every nmn brand, UTHEVER^® remains one of the few backed by clinical-grade data.

Learn more about NAD+ and how it works

Other FAQ’s About UTHEVER^® NMN

Is NMN Banned by the FDA? Is It Still Safe to Use?

NMN is generally considered safe, and fear in the coming regulatory oversight is not that it represents a safety hazard to people. Rather, the problem is how it is categorized by regulators—namely, should it be treated as a dietary supplement or a pharmaceutical compound? Now that NMN is entering into clinical trials for potential therapeutic applications, this may have triggered some regulatory barriers within the United States.

For people who are skeptical about whether NMN is a con or have doubts about its credentials, or those asking “is nmn a scam”, it should be made clear that the FDA does so out of regulatory concerns. Choosing products that are backed by clinical evidence such as those detailed in uthever nmn review or referenced in prohealth nmn review,is a better way to stay clear of low-quality and deceptive supplements on the market.

Figure NAD+ levels and their impact on health, figure source.

Is NMN Approved as a Novel Food in the EU?

Not yet. The European Food Safety Authority (EFSA) is in the process of reviewing NMN under the European Union’s Novel Food regulation framework. While the approval process is still underway, UTHEVER^® NMN leads the pack in application efforts. It has already successfully completed the public consultation phase—a critical milestone on the road to regulatory approval.

Backed by comprehensive safety and efficacy data, UTHEVER^® NMN is well positioned to become one of the first NMN brands in the entire world so entirely headquartered Europe to receive Novel Food approval in line with EU standards and regulations. This progress reinforces UTHEVER’s strength in nmn brand comparison evaluations. That could happen by 2025 at the earliest.

Reference

[1] Huang, H. (2022). A Multicentre, Randomised, Double Blind, Parallel Design, Placebo Controlled Study to Evaluate the Efficacy and Safety of UTHEVER (NMN Supplement), an Orally Administered Supplementation in Middle Aged and Older Adults. Frontiers in Aging, 3. https://doi.org/10.3389/fragi.2022.851698

[2]Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2020). NAD+ metabolism and its roles in cellular processes during ageing. Nature Reviews Molecular Cell Biology, 22(2), 119–141. https://doi.org/10.1038/s41580-020-00313-x