L-5-甲基四氢叶酸钙

L-5-甲基四氢叶酸钙是白色到淡黄色的结晶性粉末，是叶酸自然形成的钙盐衍生物，是叶酸最具生物活性和功能的形式，较普通叶酸易被吸收。L-5-甲基四氢叶酸在十多年前，已在欧洲用于药物用途，主要是用于高半胱氨酸控制，产前保健，心血管疾病、痴呆和抑郁症的治疗。

L-Methylfolate (5-MTHF) During Pregnancy

Active folic acid is highly protective against Neural Tube Defects.

This is why all national and international health organizations advocate for folic acid supplementation before and during early pregnancy. For those who do not metabolize folic acid well, supplementing L-Methylfolate is the clear alternative while pregnant. Especially if you have a homozygous C677T or A1298C mutation, which is thought to increase your folate requirements even more.

L-Methylfolate (5-MTHF) in depression

L-methylfolate is becoming widely recognised as an effective complementary medicine for patients with severe depression. That is, using italongside pharmaceutical drugs (SSRI) to enhance the overall effectiveness of treatment (much like fish oil and depression). Several randomised clinical trials have shown that 15 mg/day of L-methylfolate calcium is a safe, effective and well-tolerated treatment for patients with major depressive disorder who experience partial or no response to SSRIs. It appears to be particular effective in those with certain genetic variations (including MTHFR) and those with elevated inflammatory markers.

L-Methyfolate (5-MTHF) in patients with diabetic neuropathy

Diabetic neuropathy is nerve disorder that develops over time in those with poorly managed type 1 or type 2 diabetes.

In a recent study, 544 patients with diabetic neuropathy were given Metanx (L-methylfolate-methylcobalamin-pyridoxal-5-phosphate) to trial for over a year. Based on self-reported surveys, overall pain rating decreased by 32% those previously treated with medications reported a 52% improvement in medication satisfaction. Metanx is a combination vitamin B supplement, so this study did not test the effects of L-methylfolate on its own.

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