NMN vs NMNH (Reduced NMN): The New Player in NAD+ Boosters

Understanding the Role of NAD+ in Aging

A key factor in aging is the decline of nicotinamide adenine dinucleotide (NAD+), a vital coenzyme for energy production, DNA repair, and cellular metabolism. As NAD+ decreases with age, mitochondrial function, inflammation, and cellular repair are affected.

The idea to remedy this issue has been several NAD+ precursors like NMN and NR (nicotinamide riboside), which allow the cells to recover lost NAD+ levels through cellular health support. New to the game is NMNH, which is supposed to become a better alternative to other long-used anti-aging supplements.

NMNH vs. NMN: Which is Better

NMNH (reduced NMN), or dihydronicotinamide mononucleotide, is the reduced form of nicotinamide mononucleotide (NMN). As a potent enhancer of nicotinamide adenine dinucleotide (NAD+), NMNH plays a key role in cellular energy production and metabolic regulation.

NAD+ is scientifically recognized as a factor that affects the aging process and plays an important role in healthy cellular energy metabolism and DNA repair:

Multi-Tissue NAD+ Rise: NMNH (Reduced NMN) demonstrates superior efficiency in boosting NAD+ levels. Studies show that administration of NMNH to mice resulted in a rapid and sustained surge in NAD+ in whole blood, as well as elevated NAD+ levels in the liver, kidney, muscle, brain, brown adipose tissue, and heart. ^[¹^]
Learn more about the difference between the NMN & NMNH.

Potential Benefits of NMNH Supplements

Anti-Aging Effect: Our Phase I clinical study found that NMNH can reduce biological age markers by up to five years. Our Phase II study is designed to further explore its benefits. Meanwhile, comprehensive toxicology, preclinical studies, and self-certification have thoroughly examined its safety.
NAD+ increment: in vitro studies supported NMNH’s potential in boosting NAD+ levels. ^[¹^]^[^2]Our recent clinical study revealed the NMNH supplements effects in the real world. It demonstrated up to a 3 times increase in NAD+ levels in the 90 days of the experiment.
Energy Improvement & Emotional Health: The participant’s group has shown a significant increase in energy levels (35% increase) and emotional wellness status (31% increase). Indicating NMNH supplements have more potential for energy improvement and mood management.

Can NMNH Impact Multiple Tissues and Organs?

NMNH has a uniquely broad impact. NlMNH’s ability to increase NAD+ levels is not limited to a single type of tissue or organ. It supports heart, brain, muscle, liver, kidney, and immune function. This suggests that it has broad cellular support potential and holds promise in anti-aging, cellular health, and organ health.

This was also confirmed in mouse experiments. The results showed that NMNH triggered a rapid and sustained surge in NAD+ levels in whole blood. Increased NAD+ was also observed in key tissues and organs.^[1]

Clinical Trial Planning: Future Research of NMNH Supplements

UthPeak® is the only NMNH (reduced NMN) supplement on the market with clinically proven safety and efficacy. These tests highlight its potential for anti-aging, anti-fatigue, improved sleep quality, enhanced brain function, and cardiovascular health. We also conduct exhaustive toxicology testing on a variety of matrices to ensure that UthPeak® meets the highest standards of safety and efficacy.

By establishing UthPeak® as a safe and effective health supplement, we aim to set a new benchmark in the NAD+ booster market. Beyond safety and efficacy, these trials are designed to provide the broader scientific community with meaningful data and insights into how NMNH plays a critical role in promoting overall health and well-being.

FAQ about NMNH

Is NMNH safe? Will I have side effects?

Reduced NMN (NMNH) has passed rigorous safety checks in lab studies and early human trials, meaning solid data back it. Most users experience no side effects, and those who do report only very mild stomach discomfort that goes away quickly. Our toxicology panels and clinical data confirm reduced NMN’s high tolerability—so you can feel confident adding it to your daily routine. Of course, if you’re pregnant, nursing, or on prescription medications, it’s wise to consult your doctor first to make sure reduced NMN fits your personal health profile.

How and when should I take an NMNH supplement? When will I see results?

For best results, take one reduced NMN capsule each morning with water—no complex schedule needed. In our Phase II trial, participants noticed more energy within just two to three weeks, and by Day 90, blood tests showed up to a threefold increase in NAD+ levels. To optimize reduced NMN’s effects, follow it with a balanced diet, plenty of sleep, and light daily exercise. This simple routine delivers your daily NAD+ boost with minimal effort and unveils real anti-aging, energy, and mood improvements in under three months.

Reference:

[1] Yan Liu, Chengting Luo et al. (2021). Reduced Nicotinamide Mononucleotide (NMNH) Potently Enhances NAD+ and Suppresses Glycolysis, the TCA Cycle, and Cell Growth. J Proteome Res. 2021 May 7;20(5):2596-2606. doi: 10.1021/acs.jproteome.0c01037. Epub 2021 Apr 1

[2] Rubén Zapata-Pérez, Alessandra Tammaro et al. (2021). Reduced nicotinamide mononucleotide is a new and potent NAD+ precursor in mammalian cells and mice. The FASEB Jurnal. 16 March 2021. https://doi.org/10.1096/fj.202001826R